Endocrine Abstracts

Background: According to the literature, glucocorticoid receptor (GR) function is modulated by phosphorylation. Retinoic acid (RA) can activate some cytoplasmic kinases able to phosphorylate GR.Aim: As RA and glucocorticoids interact in neuronal cells, we investigated whether RA could modulate GR phosphorylation in such cells.Methods: HT-22 hippocampal cells were cultured 4d with or without dexamethasone (Dex, 10-6 M) or RA (10-6 M...

Brain ageing associates decreased neuronal plasticity, increased glucocorticoid and decreased retinoic acid (RA) signalling. We previously showed an interaction of these pathways on the regulation of a synaptic plasticity gene, BDNF. We thus investigated the effects of GC and RA on two BDNF-dependent genes: activity-regulated cytoskeleton protein (Arc) and Ca2+/calmodulin-dependent protein kinase II (CaMK). Dexamethasone (Dex, 10−6 M) and/or RA (10<...